Published On: Tue, Dec 28th, 2021

Omicron infection boosts neutralising immunity against Delta

Johannesburg: Omicron cases are rapidly expanding worldwide, often coupled with infections caused by the Delta variant.

Importantly, there was an enhancement of Delta virus neutralisation, which increased 4.4-fold

A new study led by an international team of researchers from South Africa, the US and Germany has now shown that the vaccine evading Omicron enhances neutralising immunity of the Delta variant.

The study, posted on pre-print server and not peer-reviewed yet, included both previously vaccinated and unvaccinated individuals who were infected with SARS-CoV-2 in the Omicron infection wave in South Africa soon after symptom onset.

The team then measured their ability to neutralise both Omicron and Delta virus at enrollment versus a median of 14 days after enrollment.

The findings showed that neutralisation of Omicron increased 14-fold over this time, showing a developing antibody response to the variant.

Importantly, there was an enhancement of Delta virus neutralisation, which increased 4.4-fold.

“The increase in Delta variant neutralisation in individuals infected with Omicron may result in decreased ability of Delta to re-infect those individuals,” said Prof Alex Sigal, a virologist at the Africa Health Research Institute.

“Comparing Omicron and Delta neutralisation showed that vaccinated participants were able to mount a better neutralising response against Delta virus, while the response in unvaccinated participants was more variable,” Sigal added.

While emerging data indicates that Omicron, at this time in the pandemic, is less pathogenic than Delta, the study outcome may have positive implications in terms of decreasing the Covid-19 burden of severe disease, he noted.

The Omicron variant of SARS-CoV-2, first identified in November 2021 in South Africa and Botswana, has been shown by us and others to have extensive but incomplete escape from immunity elicited by vaccines and previous infection, with boosted individuals showing effective neutralisation, even though vaccine and booster efficacy may wane over time.

While Omicron infections are rising steeply, many countries still have high levels of infection with the Delta variant.

The results of the study are consistent with Omicron displacing the Delta variant, “since it can elicit immunity which neutralises Delta making re-infection with Delta less likely. In contrast, Omicron escapes neutralising immunity elicited by Delta and therefore may re-infect Delta infected individuals,” Sigal said.

“The implications of such displacement would depend on whether Omicron is indeed less pathogenic than Delta. If so, then the incidence of Covid-19 severe disease would be reduced and the infection may shift to become less disruptive to individuals and society,” he noted.

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