New Delhi: The Oxford–AstraZeneca Covid-19 vaccine, a version of which is also being used in India, is made from an adenovirus isolated from chimpanzee poop, which has been genetically changed so that it is impossible for it to grow in humans.

Now known as Covid-19 Vaccine AstraZeneca, it was formerly called AZD1222

Now known as Covid-19 Vaccine AstraZeneca, it was formerly called AZD1222.

AZD1222 was co-invented by the University of Oxford and its spin-out company, Vaccitech. It uses a replication-deficient chimpanzee viral vector based on a weakened version of a common cold virus (adenovirus) that causes infections in chimpanzees and contains the genetic material of the SARS-CoV-2 virus spike protein.

After vaccination, the surface spike protein is produced, priming the immune system to attack the SARS-CoV-2 virus if it later infects the body.

The vaccine has been granted a conditional marketing authorisation or emergency use in more than 70 countries across six continents.

The Serum Institute of India (SII), the world’s largest vaccine manufacturer by volume, is manufacturing a version of the Oxford-AstraZeneca Covid-19 vaccine named ‘Covishield’ in India.

India is stepping up vaccination efforts against Covid-19 amid a renewed surge in the number of cases. The country registered 1,03,558 new coronavirus cases in the last 24 hours, the highest ever single-day spike since the onset of the pandemic last year, taking the total tally to 1,25,89,067 on Monday.